Osaka, Japan, March 2, 2026 - Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan; President and COO: Toichi Takino) announced that it has decided changes of the Board of Directors and Corporate Officers at the meeting of the Board of Directors held today. The appointments of the Board of Directors and Corporate Officers will be officially decided at the Company's 78th Ordinary General Meeting of Shareholders to be held in June 2026 and at the meeting of the Board of Directors to be held thereafter.

1. Changes of the position of the Board of Directors (scheduled for June 2026):
   All six incumbent Board of Directors will be re-appointed (no change in representatives).
   Masao Nomura, Akiko Okuno and Shusaku Nagae will be re-appointed as outside directors.
2. Changes of Corporate Officers (scheduled for April 1, 2026):
   Except for the following candidates of Corporate Officers, incumbent Corporate Officers will be re-appointed.

   	New Position	Current Position
   Toshihiro Tsujinaka	Representative Director, Senior Executive Officer / Chief Officer of CMC & Production / Chief Officer of Digital Technology / Chief Officer of Corporate Regulatory Compliance, Safety and Quality Assurance Division / Chief Officer of Business Design / Chief Officer of Affiliated companies	Representative Director, Executive Vice President / Executive Director, Corporate Strategy & Planning, HR Division
   Masaki Itoh	Corporate Executive Officer, Chief Officer of Finance & Accounting Division / Director, Corporate Research Office / President, Ono Digital health Investment, GK, President, Ono Global Reinsurance, Inc.	Corporate Executive Officer / Division Director, Corporate Strategy & Planning, Business Management Division, Business Management Department / President, Ono Digital health Investment, GK, President, Ono Global Reinsurance, Inc.
   Satoshi Takahagi	Corporate Officer / Senior Director, Sustainability Promotion	Corporate Officer / Senior Director, EHS Promotion
   Yasushi Hirota	Corporate Officer / Senior Director, EHS Promotion	Corporate Officer / Executive Director, Corporate Regulatory Compliance, Safety and Quality Assurance
   Harumi Nakano	Corporate Officer / Head of Finance & Accounting Division / Senior Director, Finance & Accounting Department	Senior Director, Corporate Strategy & Planning, Business Management Division, Finance & Accounting Department

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   The following are the appointments of the Board of Directors, Audit & Supervisory Board Members as well as Corporate Officers (scheduled for April 1, 2026).
   *: Candidates of the Board of Directors, and Audit & Supervisory Board Members for subject to approval at the 78th Annual Shareholders Meeting

   Gyo Sagara*	Representative Director, Chairman of the Board and Chief Executive Officer
   Toichi Takino*	Representative Director, President and Chief Operating Officer
   Toshihiro Tsujinaka*	Representative Director, Senior Executive Officer / Chief Officer of CMC & Production / Chief Officer of Digital Technology / Chief Officer of Corporate Regulatory Compliance, Safety and Quality Assurance Division / Chief Officer of Business Design / Chief Officer of Affiliated companies
   Masao Nomura*	Outside Director
   Akiko Okuno*	Outside Director
   Shusaku Nagae*	Outside Director
   Hironobu Tanisaka	Audit & Supervisory Board Member (full-time)
   Kiyoaki Idemitsu	Audit & Supervisory Board Member (full-time)
   Yasuo Hishiyama	Outside Audit & Supervisory Board Member
   Akiko Tanabe	Outside Audit & Supervisory Board Member
   Akira Takada	Corporate Executive Officer / Executive Director, CMC & Production
   Masaki Itoh	Corporate Executive Officer / Chief Officer of Finance & Accounting Division, Director, Corporate Research Office / President, Ono Digital health Investment, GK, President, Ono Global Reinsurance, Inc.
   Hiromu Habashita	Corporate Officer / Deputy Executive Director, Discovery & Research
   Shinji Takai	Corporate Officer / Head of Medical Affairs
   Satoshi Takahagi	Corporate Officer / Senior Director, Sustainability Promotion
   Tatsuya Okamaoto	Corporate Officer / Executive Director, Clinical Development
   Masayuki Tanigawa	Corporate Officer / Head of Business Strategy, License
   Takehiro Yamada	Corporate Officer / Senior Director, Risk & Compliance Management Department
   Hirokazu Kitada	Corporate Officer / Executive Director, Sales & Marketing, Primary Care Business Unit
   Yasushi Hirota	Corporate Officer / Senior Director, EHS Promotion
   Seishi Katsumata	Corporate Officer / Executive Director, Discovery & Research
   Kunihiko Ito	Corporate Officer / Head of Global Business
   Hitoshi Mito	Corporate Officer / Executive Director, Digital Technology / Senior Director, Business IT and DX
   Harumi Nakano	Corporate Officer / Head of Finance & Accounting Division / Senior Director, Finance & Accounting Department